Document Details

Document Type : Thesis 
Document Title :
Studying the application of high-sensitivity heart tests in Saudi clinical practice and its correlation with other regular laboratory examinations
دراسة تطبيق اختبارات القلب عالية الحساسية في الممارسة السريرية السعودية وارتباطها بالفحص المعملي العادي الآخر
 
Subject : Faculty of medicine 
Document Language : Arabic 
Abstract : Introduction: Cardiovascular diseases and acute myocardial infarction (AMI) constitute up to 32% of all deaths worldwide. hs-cTnT and I are the markers recommended by current guidelines for detecting AMI and myocardial damage. Currently, almost all available high-sensitivity cardiac troponin assays define a single diagnostic threshold value for the diagnosis of acute myocardial infarction based on the 99th percentile value for a healthy young population. So, the current study aims to assess the implementation of high-sensitivity cardiac troponins in Saudi Clinical practice for the diagnosis of coronary heart diseases and compare hs-cTnT levels with the Saudi population at different ages. Methods: Questionnaire part: a questionnaire was designed to assess the current practice of the implementation of high-sensitivity cardiac troponins in Saudi Clinical practice.A Retrospective study: Al Borg Laboratories across Saudi Arabia was the data source. Results: 10% of surveyed labs use cardiac Troponin T. While 19% use CK-MB .13%of the respondents use hs-cTnI, and 10% use hs-cTnT. Results showed a statistically significant use of conventional cardiac markers (77 %) more than hs-cTn (23%) (P < 0.01). The laboratories used inappropriate cut-off values for hs-cTn more than appropriate ones for hs-cTn (P < 0.01). 3 (9.7%) laboratories use the proper cut-off values for hs-cTn when used (P < 0.001). Surprisingly, only 1 (3.2%) of the seven laboratories use hs-cTn implemented age-specific cut-off; besides, only one laboratory implements gender-specific cut-off values (P < 0.001 and P < 0.001, respectively). Conclusion: The use of the hs-cTn for diagnosing AMI is significantly underutilized in Saudi clinical practice and needs to be in line with the latest international guidelines. There is a proven relationship between the increase in age and the increase in hs-cTn levels. Keywords: Troponins, Cardiovascular diseases, acute myocardial infarction, Cardiac biomarkers, high-sensitivity cardiac troponin 
Supervisor : Dr. Ayman Al-Samnoudi 
Thesis Type : Master Thesis 
Publishing Year : 1445 AH
2023 AD 
Added Date : Wednesday, December 27, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ياسر محمد السهليAl-Sahli, Yasser MohammedResearcherMaster 

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