Document Details

Document Type : Thesis 
Document Title :
ASSOCIATION OF NEUTROPHILS COUNT AND ASSOCIATED INFECTIONS WITH CLOZAPINE TREATMENT IN PATIENTS DIAGNOSED WITH SCHIZOPHRENIA ADMITTED TO THE ERADAH COMPLEX FOR MENTAL HEALTH, JEDDAH, SAUDI ARABIA: A RETROSPECTIVE STUDY 2021
ارتباط عدد الخلايا المتعادلة والعدوى المصاحبة أثناء العلاج بالكلوزابين في المرضى الذين تم تشخيصهم بمرض الفصام الذهاني وتم تنويمهم في مجمع إرادة للصحة النفسية ، جدة ، المملكة العربية السعودية: دراسة مرجعية عام 2021م
 
Subject : Faculty of medicine 
Document Language : Arabic 
Abstract : Background: Clozapine is a second-generation antipsychotic medication which used to treat resistant schizophrenia. However, therapy with clozapine is often complicated by side effects. Clozapine-associated neutropenia (CAN) is most prevalent during the initial month of treatment. Objectives: The aim of the study is to estimate neutropenia among patients diagnosed with schizophrenia under treatment of clozapine and identify the association between neutropenia and infections with clozapine treatment among patients with schizophrenia admitted to the Eradah and mental health complex, Jeddah, Saudi Arabia. Methodology: The study was carried out with a retrospective cohort design using medical records. Neutrophil counts calculated, clozapine dose, in addition to infections, and social and demographic data on fifty-one patients diagnosed with schizophrenia taking clozapine from 1st July 2018 to 30th June 2021.This paper adhered to the STROBE guidelines. Results: Most cases who developed neutropenia are of a mild type (11%). There was no significant association between the dose of clozapine and the occurrence of neutropenia in patients with schizophrenia. However, the Clozapine dose was statistically significantly associated with respiratory, skin, and soft tissue infection risk. Conclusion: There was a significant association between clozapine and the risk of respiratory, skin, and soft tissue infections. Moreover, age was statistically significantly associated with neutropenia occurrence. However, no statistically significant association was found between neutropenia occurrence and the other sociodemographic or clinical characteristics of the participants. Recommendation: Enforcing the importance of following the treatment protocol of clozapine among patients through periodic lab investigations as preventive precautions Key words: Clozapine, Schizophrenia, Neutropenia, Clozapine-associated neutropenia (CAN). 
Supervisor : Dr. Mohammad Al-Mahiawi 
Thesis Type : Master Thesis 
Publishing Year : 1445 AH
2023 AD 
Added Date : Tuesday, November 28, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
علاء محمد نور نورالهيNour Elahi, Alaa Mohammad NourResearcherMaster 

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