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Document Type |
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Thesis |
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Document Title |
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THE IMPLEMENTATION AND THE ROLE OF TRIGLYCERIDE /HIGH-DENSITY LIPOPROTIEN-CHOLESTEROL RATIO IN THE DIAGNOSIS OF DYSLIPIDEMIA IN SAUDI CLINICAL PRACTICE تنفيذ و دور ثلاثي الجليسريد / نسبة الليبوبروتين-الكوليستيرول عالية الكثافة في تشخيص خلل الشحميات في الممارسة السريرية السعودية |
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Subject |
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Faculty of medicine |
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Document Language |
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Arabic |
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Abstract |
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Introduction: Cardiovascular diseases (CVD) are the leading cause of mortality, accounting for 17.7 million (30%) deaths. The most common causes of cardiac diseases are ischemic and rheumatic heart diseases. Among these, 32% of female and 27% of male patients end with fatality to CVD. Triglyceride-to-HDL-Cholesterol ratio (TG/HDL) is a good predictive marker for the early assessment of CVD. A TG/HDL ratio of less than 0.87 is considered ideal. A value >1.74 is considered too high and is a high risk for coronary artery disease. TG/HDL ratio was suggested as a predictable self-governing factor for coronary artery disease. It is known that there is an increased risk of cardiovascular diseases with dyslipidemia. Therefore, this study aims to investigate the implementation of the TG/HDL ratio and other lipid profile tests in Saudi clinical laboratories. More specifically, here we present the extent of the use of the TG/HDL ratio in Saudi clinical practice to diagnose dyslipidemia.
Material and Methods: A questionnaire investigating clinical practice in implementing and reporting TG/HDL ratio was submitted to 31 biochemical laboratories in hospitals and medical centres in Saudi Arabia to evaluate the extent of implementing the TG/HDL-C ratio in Saudi clinical practice. Clinical laboratory data were obtained and subjected to statistical analysis to retrospectively investigate the use of gender-specific cut-off levels of the TG/HDL-C ratio. The data source for this retrospective study was Al Borg Laboratories across the Kingdom of Saudi Arabia.
Results: Three (9.6%) of the laboratories participating in the questionnaire responded that they use it, while 28 do not. Also, 3 (9.6%) of the laboratories participating in the questionnaire responded that they measure apoprotein particles, namely ApoA and ApoB. Four (12.9) of the laboratories answered that they measure Oxidized LDL (OxLDL). Five (16.1%) of the laboratories responded that they measure small dense LDL (sdLDL). Seven (22.6%) of the laboratories answered that they use sex-specific cut-off values for HDL. All answers were significantly lower than an equal distribution (P < 0.001). Concerning the use of calculated or direct LDL measurement, 14 (45.1%) laboratories used the calculated measurement method, 11 (35.4%) laboratories used direct LDL measurement, and 6 (19.3%) laboratories used both (P > 0.05).
Conclusion: This study revealed that Saudi clinical practice for lipid profile in general and TG/HDL ratio cut-off needs to be in line with the latest international guidelines.It is known that there is a relationship between advancing age and increasing lipid profile in general, especially triglycerides and cholesterol. So, the proper age-specific cut-off and gender-specific cut-off values of the TG/HDL ratio are mandatory in clinical practice. In addition, the use of small dense LDL, Oxidized LDL and ApoA & ApoB in Saudi clinical practice also didn't meet their diagnostic values. Finally, further studies are recommended to evaluate the impact of TG/HDL ratio cut-off values and other specific lipid biomarkers such as small dense LDL, Oxidized LDL and ApoA & ApoB in Saudi clinical practice for diagnosing and prognosis of cardiac diseases.
Keywords: Triglyceride/High-density lipoprotein (TG/HDL ratio), Cardiovascular diseases, Dyslipidemia, Cholesterol. |
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Supervisor |
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Prof. Ayman Zaky Elsamanoudy |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1445 AH
2023 AD |
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Co-Supervisor |
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Dr. Abdulhadi Bima |
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Added Date |
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Saturday, November 4, 2023 |
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Researchers
| عدنان عون القرني | Algarni, Adnan Awn | Researcher | Master | |
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