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Document Type |
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Thesis |
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Document Title |
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IMAGE QUALITY ENHANCEMENTS IN BREAST MRI rabic تحسين جودة الصورة في التصوير الثديي بالرنين المغناطيسيapstrac |
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Subject |
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Faculty of Human Sciences and Designs |
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Document Language |
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Arabic |
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Abstract |
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This thesis report tray gives a new adding point to improve and enhance breast imaging as a step to help patients to discover the breast cancer at early stage especially in case of masses where the efficiency of MRI increases compared to that of mammography and CT.
The research strategy in image enhancement is the most important step for discovering the ability of used modalities to provide images with good contrast. It concerns three axes; The image processing axis is based on development of softs for artificial contrast improvement, the quality control axis based on QC tests aiming to improve the performances of dedicated breast imaging MRI machines. MRI QC has many types of tests that come from different organizations like ECR, ACR, AAPM and. The third axis concerns natural contrast enhancement by using contrast agent based on paramagnetic or superparamagnetic materials.
The well-used contrast agent in MRI is gadolinium. But because of its price and biological effects, it becomes necessary to search other agents. Nanoferrites constitute a good solution by their lower cost and lower biological effects, but also they need to be used at lower doses. However, the perpendicular relaxivity is proportional to the square of magnetization saturation in case of superparamagnetic nanoferrites. Thus, it is question to perform nanoferrites with high magnetization saturation. The optimization of nickel rate in spinel nickel ferrites NiFe2O4 gives a maximum of saturation of 38.49emu/g for 33% rate of nickel. by the way, it had been experimentally demonstrated that the saturation increase with the size of nanoparticles. Which make it a good contrast agent.
To further improve the magnetic properties of spinel nickel ferrites, we proceeded to the doping by cooper and zinc. The doping with a rate of 0.01% of cooper gives a saturation of 27.28emu/g but a lower coercivity with a very interesting variation of the magnetization near the saturation which makes it a good contrast agent with lower artefact of magnetic field homogeneity. For the doping with zinc we obtained a mixture of materials, what is manifested by the XRD spectrum, with a very low saturation and very high coercivity which makes it not suitable as contrast agent but it can be used in drug delivery.
Keywords: Breast cancer, Spinel, MRI Contrast Agent, Nickel ferrite, Nano Doping, magnetization saturation. |
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Supervisor |
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Dr. Hatem Basbas |
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Thesis Type |
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Doctorate Thesis |
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Publishing Year |
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1445 AH
2023 AD |
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Added Date |
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Saturday, November 4, 2023 |
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Researchers
| فائق فاروق فطاني | Fatani, Faiq Farouk | Researcher | Doctorate | |
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